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CVVHF was then commenced, with corresponding decrease in VPA and ammonia levels, and recovery over a period of 7 days, being discharged on day 11 Patient 2: Peak level 795mg/L, Early institution of IHD for 6hrs on admission to ICU, then CVVHDF overnight, and a further HD session of 9 hours on day 2

In KU-57788-treated ATC cells, 8505C and Hth-7, numerous vacuoles were observed under bright-field phase-contrast microscopy (Fig